منابع مشابه
Who Pix up Rac1?
1 0. 10 83/j cb.17 25 it i1 j cb 1725 it i1 Nicole LeBrasse [email protected] for the cofilin course O n page 671 , Chen and Macara unveil a mechanism by which Par-3 orchestrates cell polarization by regulating actin reorganization. Par-3 is one member of an apical polarity-inducing complex that also includes Par-6 and aPKC. The Par...
متن کاملRegulation of the mTOR-Rac1 axis in platelet function
Small GTPase proteins regulate cytoskeletal dynamics to orchestrate diverse cellular functions in organismal physiology, development and disease. The Rho GTPase family member Rac1 is central to actin-driven processes in a number of cell types, particularly platelets, where Rac1 serves as an essential mediator of lamellipodia formation and thrombus stability. Despite the importance of Rac1 to pl...
متن کاملS6K1 and mTOR regulate Rac1-driven platelet activation and aggregation.
Platelet activation and thrombus formation are under the control of signaling systems that integrate cellular homeostasis with cytoskeletal dynamics. Here, we identify a role for the ribosome protein S6 kinase (S6K1) and its upstream regulator mTOR in the control of platelet activation and aggregate formation under shear flow. Platelet engagement of fibrinogen initiated a signaling cascade that...
متن کاملCentrosome Biogenesis: Centrosomin Sizes Things Up!
Centrosomes are composed of a centriole pair surrounded by a proteinaceous matrix of pericentriolar material that contains protein complexes required for microtubule nucleation and anchoring. Recent work reveals an intriguing link between centrioles and pericentriolar material that is involved in modulating centrosome size.
متن کاملEnhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes.
BACKGROUND/AIMS In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes (CAMs) to thereby exert their beneficial effect...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2011
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3124